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  • 名古屋大学
  • 名古屋大学理学部 生命理学科・専攻
  • World Premier International Research Center (WPI) Initiative
  • Institute of Transformative Bio-Molecules (ITbM)
  • International Association of Sexual Plant Reproduction Research




グループリーダー・名古屋大学大学院理学研究科 特任助教

名前栗原 大輔


2004年 大阪大学工学部応用自然科学科卒業

2006年 大阪大学大学院工学研究科応用生物工学専攻博士前期課程修了

2009年 大阪大学大学院工学研究科生命先端工学専攻博士後期課程修了

2009年 博士(工学)(大阪大学)


2006年4月-2009年3月 日本学術振興会特別研究員DC1(大阪大学大学院工学研究科生命先端工学専攻)

2009年4月-2010年12月 日本学術振興会特別研究員PD(名古屋大学大学院理学研究科生命理学専攻)

2011年1月- 現職


2010年9月 日本植物形態学会奨励賞




1. Kurihara D.**, Mizuta Y., Sato Y., Higashiyama T. (2015) ClearSee: a rapid optical clearing reagent for whole-plant fluorescence imaging. Development 142: 4168-4179. [PubMed]  [Article] **Corresponding author


2. Gooh K., Ueda M., Aruga K., Park J., Arata H., Higashiyama T., Kurihara D.** (2015) Live-cell imaging and optical manipulation of Arabidopsis early embryogenesis. Dev. Cell 34: 242-251. [PubMed]  [Article] **Corresponding author


3. Maruyama D., Völz R., Takeuchi H., Mori T., Igawa T., Kurihara D., Kawashima T., Ueda M., Ito M., Umeda M., Nishikawa S., Groß-Hardt R., Higashiyama T. (2015) Rapid elimination of the persistent synergid through a cell fusion mechanism. Cell 161: 907-918. [PubMed]  [Article]


4. Susaki D., Takeuchi H., Tsutsui H., Kurihara D., Higashiyama T. (2015) Live imaging and laser disruption reveal the dynamics and cell-cell communication during Torenia fournieri female gametophyte development. Plant Cell Physiol. 56: 1031-1041. [PubMed]  [Article]


5. Mizuta Y., Kurihara D., Higashiyama T. (2015) Two-photon imaging with longer wavelength excitation in intact Arabidopsis tissues. Protoplasma in press [PubMed]  [Article]


6. Sasabe M., Ishibashi N., Haruta T., Minami A., Kurihara D., Higashiyama T., Nishihama R., Ito M., Machida Y. (2015) The carboxyl-terminal tail of the stalk of Arabidopsis NACK1/HINKEL kinesin is required for its localization to the cell plate formation site. J. Plant Res. 128: 327-336. [PubMed]  [Article]


7. Hasegawa J., Higaki T., Hamamura Y., Kurihara D., Kutsuna N., Higashiyama T., Hasezawa S., Matsunaga S. (2014) Increase in invaginated vacuolar membrane structure caused by plant cell expansion by genotoxic stress induced by DNA double-strand breaks. Cytologia 79: 467-474. [Article]  


8. Hamamura Y., Nishimaki M., Takeuchi H., Geitmann A., Kurihara D., Higashiyama T. (2014) Live imaging of calcium spikes during double fertilization in Arabidopsis. Nat. Commun. 5: 4722. [PubMed]  [Article]


9. Maruyama D., Hamamura Y., Takeuchi H., Susaki D., Nishimaki M., Kurihara D., Kasahara R.D., Higashiyama T. (2013) Independent control by each female gamete prevents the attraction of multiple pollen tubes. Dev. Cell 25: 317-323. [PubMed]  [Article]


10. Luo L., Ando S., Sasabe M., Machida C., Kurihara D., Higashiyama T., Machida Y. (2012) Arabidopsis ASYMMETRIC LEAVES2 protein required for leaf morphogenesis consistently forms speckles during mitosis of tobacco BY-2 cells via signals in its specific sequence. J. Plant Res. 125: 661-668.  [PubMed]  [Article]


11. Adachi, S., Minamisawa, K., Okushima, Y., Inagaki, S., Yoshiyama, K., Kondou, Y., Kaminuma, E., Kawashima, M., Toyoda, T., Matsui, M., Kurihara, D., Matsunaga, S., Umeda, M. (2011) Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis. Proc Natl Acad Sci USA. 108: 10004-9.   [PubMed]  [Article]


12. Kurihara, D., Matsunaga, S., Omura, T., Higashiyama, T., Fukui, K. (2011) Identification and characterization of plant Haspin kinase as a histone H3 threonine kinase. BMC Plant Biol. 11: 73.   [PubMed]  [Article]


13. Hamamura, Y., Saito, C., Awai, C., Kurihara, D., Miyawaki, A., Nakagawa, T., Kanaoka, M.M., Sasaki, N., Nakano, A., Berger, F., Higashiyama, T. (2011) Live-Cell Imaging Reveals the Dynamics of Two Sperm Cells during Double Fertilization in Arabidopsis thaliana. Curr. Biol.21: 497-502.   [PubMed]  [Article]


14. Goto, H., Okuda, S., Mizukami, A., Mori, H., Sasaki, N.,Kurihara, D., Higashiyama, T. (2011) Chemical visualization of an attractant peptide, LURE. Plant Cell Physiol. 52: 49-58.   [PubMed]  [Article]


15. Kurihara, D., Matsunaga, S., Uchiyama, S., Fukui, K. (2008) Live cell imaging reveals plant aurora kinase has dual roles during mitosis. Plant Cell Physiol. 49: 1256-1261.   [PubMed]  [Article]


16. Morimoto, A., Matsunaga, S., Kurihara, D., Fukui, K. (2008) Visualization of mitotic HeLa cells by advanced polarized light microscopy. Micron 39: 635-638.   [PubMed]  [Article]


17. Cartagena, J.A., Matsunaga, S., Seki, M., Kurihara, D., Yokoyama, M., Shinozaki, K., Fujimoto, S., Azumi, Y., Uchiyama, S., Fukui, K. (2008) The Arabidopsis SDG4 contributes to the regulation of pollen tube growth by methylation of histone H3 lysines 4 and 36 in mature pollen. Dev. Biol. 315: 355-368.   [PubMed]  [Article]


18. Takata, H., Matsunaga, S., Morimoto, A., Ma, N., Kurihara, D., Ono-Maniwa, R., Nakagawa, M., Azuma, T., Uchiyama, S., Fukui, K. (2007) PHB2 protects sister-chromatid cohesion in mitosis. Curr. Biol. 17: 1356-1361.   [PubMed]  [Article]


19. Watanabe, W., Shimada, T., Matsunaga, S., Kurihara, D., Fukui, K., Arimura, S., Tsutsumi, N., Isobe, K., Itoh, K. (2007) Single-organelle tracking by two-photon conversion. Opt. Exp. 15: 2490-2498.   [PubMed]  [Article]


20. Kurihara, D.*, Kawabe, A.*, Matsunaga, S., Nakagawa, K., Fujimoto, S., Uchiyama, S., Fukui, K. (2007) Characterization of a splicing variant of plant Aurora kinase. Plant Cell Physiol. 48: 369-374. *These authors equally contributed to this work.   [PubMed]  [Article]


21. Kurihara, D., Matsunaga, S., Kawabe, A., Fujimoto, S., Noda, M., Uchiyama, S., Fukui, K. (2006) Aurora kinase is required for chromosome segregation in tobacco BY-2 cells. Plant J. 48: 572-580.   [PubMed]  [Article]


22. Kawabe, A.*, Matsunaga, S.*, Nakagawa, K., Kurihara, D., Yoneda, A., Hasezawa, S., Uchiyama, S., Fukui, K. (2005) Characterization of plant Aurora kinases during mitosis. Plant Mol. Biol. 58: 1-13. *These authors equally contributed to this work.   [PubMed]  [Article]



1. Kurihara D., Matsunaga S. (2014). Kinetochore and microtubule dynamics during cell division of tobacco BY-2 cells visualized by live-cell imaging. In Atlas of Plant Cell Structure, Noguchi et al. ed. Springer, 16-17.


2. 水多陽子, 栗原大輔. (2014) 2 光子励起顕微鏡を用いた生体深部イメージングと光顕微操作. 植物の生長調節49: 96-103.


3. 水多陽子, 栗原大輔, 東山哲也. (2014) 2光子顕微鏡による植物深部のin vivoイメージング. Plant Morphology 26: 25-30.


4. Kurihara D., Hamamura Y., Higashiyama T. (2013) Live-cell analysis of plant reproduction: live-cell imaging, optical manipulation, and advanced microscopy technologies. Dev. Growth. Differ. 55: 462-473.   [PubMed]  [Article]


5. 栗原大輔(2011) 細胞分裂期において分裂期キナーゼが制御する染色体動態.Plant Morphology23: 81-89.


6. 栗原大輔(2010) 生物学事典, 東京化学同人, 分担執筆.


7. 栗原大輔, 松永幸大. (2009) 染色体動態−染色体の動き、動物と植物の共通点と違い. 生物の科学遺伝63: 55-60.


8. Kurihara, D., Matsunaga, S., Uchiyama, S. Fukui, K. (2008) Plant Aurora kinase has dual roles on chromosome alignment and segregation during mitosis. Cytologia 73: 1-2.  [Article]


9. 松永幸大, 栗原大輔, 中園幹生. (2006) 植物におけるヒストン翻訳後修飾研究の幕開け. 化学と生物44: 798-799.


10. Kurihara, D., Matsunaga, S., Fukui, K. (2006) Chromosome dynamics in Arabidopsis. Plant Genome: Biodiversity and Evolution. Edited by Sharma, A.K. and Sharma, A. Science Publishers, Enfield, New Hampshire, USA. 127-147.


11. Matsunaga, S., Kurihara, D., Kawabe, A., Nakagawa, K., Yoneda, A., Hasezawa, S., Uchiyama, S. Fukui, K. (2005) Dynamics of the plant Aurora kinase AtAUR3 during mitosis and spindle abnormality induced by AtAUR3 overexpression. Cytologia 70: 1-2.  [Article]

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